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KMID : 0605620070140040262
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Journal of Korean Society of Biological Psychiatry
2007 Volume.14 No. 4 p.262 ~ p.267
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No Association between the 5-HT6 Receptor C267T Polymorphism and Response to Citalopram Treatment in Patient with Major Depressive Disorder
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Han Sang-Woo
Lim Se-Won
Oh Kang-Seob
Kang Rhee-Hun
Lee Min-Soo
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Abstract
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Objectives:The serotonin 6(5-HT6) receptor gene is a candidate gene for influencing the clinical response to treatment with antidepressants. The purpose of this study was to determine the relationship between the C267T polymorphism in the 5-HT6 receptor gene and the treatment response to citalopram in a Korean population with major depressive disorder(MDD).
Methods：Citalopram was administered for 8 weeks to the 90 patients who completed study. 21-item Hamilton depression rating scale(HAMD-21) was used as a outcome measure.
Results：We found that the genotype, allele, and allele-carrier distributions did not differ significantly between MDD patients and normal controls. A main effect of an interaction of genotype with time on the decrease in the HAMD-21 score during the 8 weeks study period was not found. ANOVA revealed no significant effects of the C825T polymorphism on the decrease in the HAMD-21 score at each time period.
Conclusions：These results suggest that the C267T polymorphism in the 5-HT6 receptor gene is not associated with the treatment response to citalopram.
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KEYWORD
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MDD, Major depressive disorder, 5-HT6 receptor, C267T polymorphism, Citalopram.
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